Optimized PHP & WordPress settings for speed/performance?

I have a big site with several plugins that take up memory, a lot of requests to the server, etc. I’ve maxxed out my hosting to help account for this, but are there optimum PHP and WordPress settings for big heavy site, or just optimum PHP base settings for WordPress period.

Here are my current settings:

allow_url_fopen = Disabled
allow_url_include = Disabled
display_errors = Enabled
enable_dl = Disabled
file_uploads = Enabled
max_execution_time = 600
max_input_time = 400
max_input_vars = 10000
memory_limit = 128M
session.save_path = (blank)
upload_max_filesize = 2M

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